The permeability glycoproteinP-glycoprotein 1, abbreviated as P-gp or Pgp also known asMDR1(MultiDrug Resistance protein 1-MDR1), is encoded by theABCB1gene.
The proteome is the totalset of proteins contained in a cell.It is a transmembrane protein of “extrusion”, that is, it transports metabolites like drugs, inside the cell to the outside.From the enterocyte to the intestinal lumen, from the hepatocyte to the bile or to the blood, from the cells of the renal tubules to the urine. In the brain it is a fundamental part of the so-called “blood-brain barrier” and is also part of the structures of the fetus-placental barrier.Regarding to medications, genetic polymorphisms ofABCB1and some drug interactions, can alter their activity, their effectiveness or be a cause of toxic reactions.
Dr. Juan Sabater-TobellaEuropean Specialist in Clinical Chemistry and Laboratory Medicine (EC4)Member of the Pharmacogenomics Research NetworkMember of the International Society of Pharmacogenomics and Outcomes ResearchPresidente de EUGENOMIC®
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Last modified: Mar 28, 2018 @ 11:27 am
Last modified: Nov 8, 2018 @ 5:56 pm